China has confirmed that four more people in one province are seriously ill with a bird flu virus new to humans that has already killed two people.
The health bureau of eastern Jiangsu province said on its website that three women, aged 45, 48 and 32, and an 83-year-old man, from different cities in the province, were all critically ill with the H7N9 virus.
One of the patients, from Nanjing city, worked slaughtering live poultry, but the others had no such contact.
The four cases did not appear to be connected, and people who have had close contact with the patients have not reported any symptoms, it said.
The provincial health bureau said it was strengthening measures to monitor suspicious cases and urged the public to stay calm.
It joins Beijing and China's financial capital, Shanghai, in rolling out new steps to respond to the relatively unknown virus.
The four latest cases follow three earlier ones reported on Sunday, including two men who died in Shanghai earlier in March.
A news conference on bird flu was held in Shanghai The city responded by activating an emergency plan that calls for heightened monitoring of suspicious flu cases in schools, hospitals and retirement facilities.
The level-3 response plan, the second-lowest in a four-stage scale, reflects higher concern after the H7N9 bird flu virus led to the deaths of two men in Shanghai and left a woman seriously ill in the city of Chuzhou 230 miles west.
"The health bureau will take effective and powerful measures to prevent and control the disease, to make sure the flu epidemic is effectively guarded against and to safeguard the health of the city's residents," said Xu Jianguang, head of the Shanghai Health Bureau.
The H7N9 strain, so named for the combination of proteins on its surface, has previously been considered not easily transmitted to humans.
The more virulent H5N1 strain, which began ravaging poultry across Asia in 2003, has since killed 360 people worldwide. China has reported two deaths from that strain this year.
Health officials said this week there was no evidence that any of the three earlier H7N9 cases, who were infected over the past two months, had contracted the disease from each other, and no sign of infection in the 88 people who had closest contact with them.
The World Health Organisation (WHO) has played down fears over the new type of bird flu, but said it was crucial to find out how the virus infected humans.
"It is of concern to WHO and we will be following this with the health authorities in China to know more," spokeswoman Fadela Chaib said before the new cases were announced.
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